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The risk of developing steroid-induced type 2 diabetes is highest in people who are taking large doses of steroids over extended periodsof time, and that risk increases as the dosage increases, according to the researchers.The study, which was published online August 19 in The Journal of Clinical Endocrinology & Metabolism, is being funded and co-authored by Dr. Peter A. Piotrowski, professor of medicine at the University of Michigan's Ross School of Medicine, and researcher Dr. Mark Hyman, director of the Endocrine Diabetes Center at Harvard-affiliated Brigham and Women's Hospital.The researchers studied 3,541 men and women ages 70 and up who had at least one year of regular steroid use. Of these participants, 9% were using steroids daily, and 13% had used them weekly for at least 6 months.At baseline, the men had a greater risk of developing type 2 diabetes over a period of 12 years than did the women, the researchers found."We found that an increased risk of type 2 diabetes was present both in men and women who were regular users of steroids," said Dr. Christopher A. Alpern, study senior author and physician at the New York-Presbyterian Hospital and Columbia University Medical Center. "As the drug-related problems can be treated successfully with diet and physical activity, this raises the possibility of future clinical trials aimed at identifying the risk factors for the development of type 2 diabetes."In addition, the researchers were able to identify the specific types of steroids involved and determine how frequently these users were initiating steroid use. The risk of type 2 diabetes was significantly increased in users of anabolic androgenic steroids compared with those who were never using steroid medicines.The increased risk of type 2 diabetes in users over longer periods of time was also evident in women, who had an increased risk of developing the disease."Our data suggest that the initiation of steroid use among adult females could lead to a higher risk of type 2 diabetes; however, our results also indicated that, given the lower risk in the current-aged women, future work in this domain should focus on developing more effective methods of screening and monitoring young adolescents and individuals of all ages," Dr. Alpern concluded.###The paper, "The association between age and risk of developing type 2 diabetes in men and women," was co-authored by Tatsuya Shimamoto, M.D., the Samuel O. T. Smith University Professor in the Department of Medicine; and Dr Mark Hyman, associate professor of medicine at Massachusetts General Hospital and professor ofSimilar articles: